the effect of l-arginine supplementation on blood pressure in patients with type 2 diabetes: a double-blind randomized clinical trial

نویسندگان

sara asadi nutrition and food security research center, shahid sadoughi university of medical sciences, yazd, iran

hassan mozaffari-khosravi nutrition and food security research center, shahid sadoughi university of medical sciences, yazd, iran

mohammad mahdi naghizade fasa university of medical sciences and health services, fasa, iran

azadeh nadjarzadeh department of nutrition, school of public health, shahid sadoughi university of medical sciences, yazd, iran

چکیده

introduction: the prevalence of hypertension in patients with type 2 diabetes (t2d) is approximately twice as much as healthy people. this study was designed to determine the effect of l-arginine supplementation on blood pressure in patients with t2d. methods: in a double-blind randomized clinical trial, 75 t2d were randomly divided into three groups (3 g/d and 6 g/d of l-arginine and placebo) for 3 months. height, weight, waist circumference, dietary intake, and blood pressure (bp) were measured before and after intervention. results: in patients who received 3 g/d l-arginine, no significant difference was observed between bp before and after the intervention, however, subgroup analysis among patients with high bp showed significant reduction in systolic (p = 0.036) and diastolic  bp (p = 0.027) after l-arginine supplementation.  after 3 months of intervention, systolic and diastolic bp were significantly different compared to the baseline values and also with placebo value in patients receiving 6g/d of l-arginine (p < 0.05). conclusion: the daily intake of 6 g of l-arginine for 3 months in t2d may improve bp. taking 3 g/d of this supplement may help to improve bp only in patients with hypertension.

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